@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA53lKUOc0v3Wf9p-eu9XEYSYqDFig8d3cOVhJF6cRucc> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA53lKUOc0v3Wf9p-eu9XEYSYqDFig8d3cOVhJF6cRucc#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix pfh: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: pfh:PRKA%20Family;
    a Protein: .
  
  sub:_3 belv:variantOf hgnc:8778;
    a proteinModification:, psimod:00696 .
  
  sub:_4 occursIn: atcc:CCL-2.aspx, species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(p(PFH:\"PRKA Family\")) => p(HGNC:PDE3A,pmod(P,S,312))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "1.4" .
  
  sub:_5 prov:value "Forskolin did not promote the binding of 14-3-3 proteins to PDE3A (Figures 2A and 5A). However, using the pSer312-PDE3A antibodies, we found that forskolin stimulated the phosphorylation of PDE3A at Ser312 (Figures 5A and 5C). This residue lies within a sequence SHRRTS312LPCIP that conforms to a consensus site for PKA. The forskolin-stimulated phosphorylation of Ser312 was inhibited by the PKA inhibitor H-89 (Figure 5C), and by mimosine and aphidicolin (Figure 5A), but not by inhibitors of PI3K (LY 294002), mTOR (mammalian target of rapamycin) (rapamycin) or the MAPK cascade (U0126) (Figure 5C; see [35] for inhibitor specificities), nor by H-7 (results not shown).";
    prov:wasQuotedFrom pubmed:16153182 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:16153182;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:38.000+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}