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[Thoracic aortic aneurysm and dissection (TAAD) are associated with connective tissue disorders like Marfan syndrome and Loeys-Dietz syndrome, caused by mutations in the fibrillin-1, the TGF?-receptor 1- and -2 genes, the SMAD3 and TGF?2 genes, but have also been ascribed to ACTA2 gene mutations in adults, spread throughout the gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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