sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "1.4" . sub:_5prov:value "Transfection of U87MG and T691 cells with Gab1 and SHP-2 independently with NF-kB-luciferase reporter construct which showed a 9-fold increase in luciferase activity in both U87MG transfected cells and U87MG/T691 compared with the empty vector and cotransfection of Gab1 with SHP-2 resulted in additional upregulation of NF-kB activity. Furthermore, cotransfection with a construct expressing myristoylated Akt increased NF-kB activity in parental and T691 cells by 4 and 3-fold respectively over the empty vector but no change when expressed with mutant Akt. Stimulation with EGF resulted in the robust activation of NFkB and showed a binding complex,suggesting that p65/p50 were involved in EGFR-mediated signalling." ; prov:wasQuotedFrompubmed:14701753 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:14701753 ; prov:wasDerivedFrombeldoc: , sub:_5 . }