. . . . . . . . . . . . . . . "p(HGNC:MAPK1) -> p(HGNC:RPS6KA5,pmod(P))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to UV radiation, and oxidative and chemical stress. The activation of MSK1 by growth factors/phorbol esters is prevented by PD 98059, which suppresses activation of the MAPK cascade, while the activation of MSK1 by stress stimuli is prevented by SB 203580, a specific inhibitor of SAPK2/p38. The activated MSK1 translocates to nucleus and activates CREB by phosphorylating at serine 133." . . "Selventa" . . . . "2014-07-03T14:34:13.099+02:00"^^ . . .