@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA4R0wljRMUBin9ZZzjf68yrdRMOpBvgBJ8aezNAs9_RQ> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA4R0wljRMUBin9ZZzjf68yrdRMOpBvgBJ8aezNAs9_RQ#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0005215 .
  
  sub:_2 geneProductOf: hgnc:10484;
    a Protein: .
  
  sub:_3 occursIn: obo:CL_0000746, obo:UBERON_0000948, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject schem:Calcium;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(SCHEM:Calcium) -> tport(p(HGNC:RYR2))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_4 dce:identifier "Golan Document";
    dce:title "Golan Document";
    dce:type "Other" .
  
  sub:_5 prov:value "In the SR, the calcium release channel (ryanodine recpetor) and the calcium pump (sarcoerndoplasmic reticulum calcium ATPase, SERCA) are critical to the regulation of contractility. Proper contraction requires both that Ca2+ release into the cytoplasm is adequate to stimulate contraction and that Ca2+ reuptake into the SR is sufficient to permit relaxation and to replenish calcium stores. Cytoplasmic concentrations of both calcium and ATP regulate the activity of both the ryanodine receptor and SERCA. As noted above, trigger calcium opens the ryanodine receptor. Cytoplasmic calcium concentration is directly related to the number of receptors that open. A safety mechanism also exists whereby high calcium levels lead to calcium-calmodulin complex formation: this complex inhibits calcium release by decreasing the open time of the ryanodine receptor. High concentrations of ATP favor the open channel conformation, and thereby facilitate SR calcium release into the cytosol. ";
    prov:wasQuotedFrom sub:_4 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource sub:_4;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:31:29.117+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}