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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#_3 http://www.w3.org/ns/prov#value Inhibition of apoptosis, resulting from an increase in anti-apoptotic protein, plays a fundamental role in carcinogenesis. Because ICBP90 gene expression is deregulated in cancer cells, we studied its expression in Jurkat cells under apoptotic conditions to see whether ICBP90 is involved in the regulation of apoptosis. We found that ICBP90 expression and the percentage of living cells were dose-dependently decreased in PHA and ionophore A23187-stimulated Jurkat cells, but not in THP-1 cells. These results suggest that apoptosis is dependent upon ICBP90 expression downregulation and that ICBP90 exhibits anti-apoptotic properties. http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15033738 http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15033738 http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#_3 http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY#pubinfo http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY http://purl.org/dc/terms/created 2014-07-03T14:32:18.428+02:00 http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA4O-4JziRchgs1pNgntFZzscZ69CGr-4d4jNNUw_aXgY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234