. . . . . . . . . . . . . "a(CHEBI:nicotine) -> p(HGNC:FOXO1,pmod(P,S,256))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "five proteins previously identified to be downstream of Akt at the time of maximal nicotinic Akt induction: a member of the forkhead transcription factor family (FKHR), GSK-3? and -3?, a ribosomal kinase (p70S6K), and a binding protein for eukaryotic translation initiation factor 4E (4EBP-1) (Figure 2b). We observed different patterns of phosphorylation induced by nicotine or NNK. Nicotine increased the phosphorylation of all downstream substrates, but phosphorylation of GSK-3? and FKHR was induced most. NNK increased phosphorylation of all downstream substrates except FKHR and had the greatest effects on phosphorylation of GSK-3? and p70S6K" . . "Selventa" . . . . "2014-07-03T14:31:57.813+02:00"^^ . . .