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[The maps indicated that mutations affecting major ligand-binding sites, for example, for Von Hippel Lindau (VHL) protein in the ?1 chain or integrins in the ?5 chain, resulted in distinctive phenotypes (Hereditary Angiopathy, Nephropathy, Aneurysms, and muscle Cramps [HANAC] syndrome, and early-onset Alport syndrome, respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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