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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#_4 http://www.w3.org/ns/prov#value As shown in Fig. 6, the canonical MAP kinase pathway contains a cascade of kinase activation. Typically, an external signal or event eventually activates a MAP3K that then activates a MAP2K, which finally activates the MAPK (ERK, p38, JNK). In the p38MAPK branch, the directly relevant upstream kinases are MKK3 and MKK6, which appear to have redundant functions. Ask1, MEKK3 and Tak1 are amongst several possible MAP3K candidates for the p38MAPK branch, although these MAP3K often activate multiple MAPK pathways (reviewed in Kyriakis and Avruch, 2001). The focus of this section will be on the p38MAPK and MKK3/MKK6. Two early studies suggested that p38 MAPK activity leads to the repression of the Cyclin D1 promoter and to inhibition of G1 progression (Lavoie et al., 1996 and Molnar et al., 1997). http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15225871 http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15225871 http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#_4 http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI#pubinfo http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI http://purl.org/dc/terms/created 2014-07-03T14:30:25.335+02:00 http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA4C8BoBtBg5CKCFB_BMcR_HCF8yQfGj4lJ3Nd9pLmxtI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234