sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "As shown in Fig. 6, the canonical MAP kinase pathway contains a cascade of kinase activation. Typically, an external signal or event eventually activates a MAP3K that then activates a MAP2K, which finally activates the MAPK (ERK, p38, JNK). In the p38MAPK branch, the directly relevant upstream kinases are MKK3 and MKK6, which appear to have redundant functions. Ask1, MEKK3 and Tak1 are amongst several possible MAP3K candidates for the p38MAPK branch, although these MAP3K often activate multiple MAPK pathways (reviewed in Kyriakis and Avruch, 2001). The focus of this section will be on the p38MAPK and MKK3/MKK6.  Two early studies suggested that p38 MAPK activity leads to the repression of the Cyclin D1 promoter and to inhibition of G1 progression (Lavoie et al., 1996 and Molnar et al., 1997)." ;
    prov:wasQuotedFrom pubmed:15225871 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15225871 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}