sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "20131211" . sub:_5prov:value "In agreement with the role of S62 phosphorylation on reporter gene expression, the hTERT and Bmi-1 genes were repressed by IFN-? + TPA and by the Cdk2 inhibitor CVT-313 (Fig. 6D), whereas the p21 and p16Ink4A genes were strongly induced (Fig. 6E). The changes in gene expression are consistent with the ChIP results and indicate that cyclin E/Cdk2 enhances, whereas IFN-?, through the activation of p27, represses Myc-activated transcription (and vice versa for Myc-repressed transcription) of genes involved in cellular senescence. " ; prov:wasQuotedFrompubmed:19966300 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:19966300 ; prov:wasDerivedFrombeldoc: , sub:_5 . }