http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#Head http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#assertion http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#provenance http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#assertion http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/AMP%20Activated%20Protein%20Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/AMP%20Activated%20Protein%20Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_1 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/serum%20leptin http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"serum leptin") -> kin(complex(SCOMP:"AMP Activated Protein Kinase Complex")) http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_3 http://www.w3.org/ns/prov#value Interestingly, it has been previously reported that leptin and adiponectin can stimulate AMPK (19, 22). However, in the rats injected with Adv-resistin, the inhibition of AMPK activation appeared to be independent of adiponectin or leptin levels, as the levels of these two adipokines were not altered by hyper-resistinemia (leptin: Adv-resistin, 7.03 2.56 ng/ml; Adv-lacZ, 7.74 3.12 ng/ml; adiponectin: Adv-resistin, 8.66 1.1 ul/ml; Adv-lacZ, 7.94 2.30 ul/ml; Table 1). We found a uniform decrease in AMPK activity as measured by AMPK phosphorylation, in liver, muscle, and fat. Interestingly, however, it is known that both leptin and adiponectin can increase AMPK activity, but as leptin and adiponectin levels were comparable between the rats injected with Adv-resistin and those injected with Adv-lacZ, and as resistin is an adipokine that generally has effects opposite to those of leptin and adiponectin, it is likely that resistin decreases AMPK activity. http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15254589 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15254589 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#_3 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://purl.org/dc/terms/created 2014-07-03T14:32:25.923+02:00 http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3zHEKEm16Xgt8ta7A0Mr2PvPdW3ifVa8xXng2sl0_ic http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234