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[Additionally, cell biology studies suggest that there is little exchange between circulating and brain cholesterol, that increased membrane cholesterol is protective by inhibiting loss of membrane integrity through amyloid cytotoxicity, and that cellular cholesterol inhibits co-localization of BACE1 and A?PP in non-raft membrane domains, thereby increasing generation of plasmin, an amyloid-?-degrading enzyme.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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