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a(CHEBI:lipopolysaccharide) -> r(MGI:Tap2)
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Approximately 61,000 statements.
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In livers of LPS-treated mice, we observed coordinate induction of genes whose products act in concert to present endogenous antigens (Fig. 4). This wave of increased expression, sustained between 3 and 12 h after LPS administration, included genes for the specialized proteasome components LMP2 (psmb9), LMP7 (psmb8), LMP10 (psmb10), PA28 (psme1), and PA28 (psme2); the peptide transporter components Tap1 (abcb2) and Tap2 (abcb3); the accessory protein tapasin (tapbp); and MHC class II proteins (H2-k, H2-d; Fig. 4 A and B). Transcripts for the constitutive proteasome -subunit 2 (psma2) were also increased, albeit slightly (Fig. 4 A and B).
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