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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#_6 http://www.w3.org/ns/prov#value We show here in cultured tamarin hepatocytes that GBV-B NS3/4A protease, but not a related catalytically inactive mutant, effectively blocks innate intracellular antiviral responses signaled through the RNA helicase, retinoic acid-inducible gene I (RIG-I), an essential sensor molecule that initiates host defenses against many RNA viruses, including HCV. GBV-B NS3/4A protease specifically cleaves mitochondrial antiviral signaling protein (MAVS; also known as IPS-1/Cardif/VISA) and dislodges it from mitochondria, thereby disrupting its function as a RIG-I adaptor and blocking downstream activation of both interferon regulatory factor 3 and nuclear factor kappa B. http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17093192 http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17093192 http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#_6 http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ http://purl.org/dc/terms/created 2014-07-03T14:33:06.652+02:00 http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234