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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#_3 http://www.w3.org/ns/prov#value Precise temporal and spatial coordination of proteolytic and nonproteolytic mechanisms is responsible for the succession of events during cell migration. With a non-proteolytic mechanism, uPA would stimulate cell migration by enhancing adhesion at the leading edge, through stimulation of binding of uPAR to vitronectin, modulation of uPAR/integrin interaction and/or by initiation of signal-transduction cascade that results in the cytoskeleton reorganization and in the cell \"dragging up\" to the leading edge. The proteolytic mechanisms include uPA catalyzed plasmin generation at focal adhesion sites that results in extracellular matrix degradation and thus facilitate detachment of the trailing edge. Both mechanisms could be operating simultaneously in the individual migrating cell. The role of PAI-1 in migration depends on its pericellular localization. The anti-migrational effect of PAI-1 seems to be associated with suppression of plasmin generation on the ventral surface of the cell, preventing its unfastening, with an inhibition of vitronectin binding to integrins and to uPAR on the leading edge. http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11841347 http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11841347 http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#_3 http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc http://purl.org/dc/terms/created 2014-07-03T14:31:46.906+02:00 http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234