@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix do: <http://disease-ontology.org/term/DOID:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:8583;
    a Protein: .
  
  sub:_2 occursIn: do:1936, obo:CLO_0008947, obo:CL_0000576, obo:UBERON_0004535, species:9606;
    rdf:object go:0016477;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:SERPINE1) -| bp(GOBP:\"cell migration\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Precise temporal and spatial coordination of proteolytic and nonproteolytic mechanisms is responsible for the succession of events during cell migration. With a non-proteolytic mechanism, uPA would stimulate cell migration by enhancing adhesion at the leading edge, through stimulation of binding of uPAR to vitronectin, modulation of uPAR/integrin interaction and/or by initiation of signal-transduction cascade that results in the cytoskeleton reorganization and in the cell \\\"dragging up\\\" to the leading edge. The proteolytic mechanisms include uPA catalyzed plasmin generation at focal adhesion sites that results in extracellular matrix degradation and thus facilitate detachment of the trailing edge. Both mechanisms could be operating simultaneously in the individual migrating cell. The role of PAI-1 in migration depends on its pericellular localization. The anti-migrational effect of PAI-1 seems to be associated with suppression of plasmin generation on the ventral surface of the cell, preventing its unfastening, with an inhibition of vitronectin binding to integrins and to uPAR on the leading edge.";
    prov:wasQuotedFrom pubmed:11841347 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11841347;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:31:46.906+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}