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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#_7 http://www.w3.org/ns/prov#value Summary: Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12244094 http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12244094 http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#_7 http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk http://purl.org/dc/terms/created 2014-07-03T14:30:06.034+02:00 http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3dGcy0WAD_E5X_t791ReXei5q39liw3BpPxozST4jsk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234