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(complex(p(HGNC:CD3D),p(HGNC:CD3G),p(HGNC:CD3E),p(HGNC:CD28)) -> tscript(complex(SCOMP:"Nfkb Complex"))) http://www.tkuhn.ch/bel2nanopub/RA3bhcDsl5z2Ol6thGy2dv3tmV3Nx5sscdt238LlfTz8U#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3bhcDsl5z2Ol6thGy2dv3tmV3Nx5sscdt238LlfTz8U#_11 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3bhcDsl5z2Ol6thGy2dv3tmV3Nx5sscdt238LlfTz8U#_10 http://www.w3.org/ns/prov#value Using a CARD-deleted variant of CARD11 and RNA interference (RNAi), we demonstrate that CARD11 mediates NF-kappaB activation by alphaCD3/alphaCD28 cross-linking and PMA/ionomycin treatment, but not by TNFalpha or dsRNA. CARD11 is not required for TCR-mediated induction of NFAT or AP-1. 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