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p(SFAM:"PRKA Family") -> p(HGNC:CREB1,pmod(P,S,133))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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Moreover, PP1 was shown to act as a major CTD phosphatase in nuclear extracts and to affinity-purify with RNA polymerase II. Both PP1 and the nuclear regulator NIPP1 have also been identified as components of the Tat-associated RNA polymerase II complex, which regulates transcription from the human immunodeficiency virus type 1 promoter (40, 275). The transcription factor CREB mediates the expression of cAMP-induced genes by binding to a conserved cAMP-responsive element. Phosphorylation of CREB on Ser-133, e.g., by PKA, promotes the recruitment of the histone acetyltransferase CBP, which facilitates access of the promoter region to the transcriptional machinery.
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Selventa
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2014-07-03T14:32:14.593+02:00
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