@prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dct: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix Protein: . @prefix hgnc: . @prefix geneProductOf: . @prefix go: . @prefix species: . @prefix occursIn: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 geneProductOf: hgnc:1100; a Protein: . sub:_2 occursIn: species:9606; rdf:object go:0008219; rdf:predicate belv:increases; rdf:subject sub:_1; a rdf:Statement . sub:assertion rdfs:label "p(HGNC:BRCA1) -> bp(GO:\"cell death\")" . } sub:provenance { beldoc: dce:description "Approximately 61,000 statements."; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved."; dce:title "BEL Framework Large Corpus Document"; pav:authoredBy sub:_4; pav:version "1.4" . sub:_3 prov:value "This model for reciprocal regulation of nuclear transport by NES masking is unique in the literature, although it is certainly possible that other heterodimers are regulated in a similar fashion. It is not yet known whether BRCA2 is regulated by nuclear-cytoplasmic shuttling. Functional implications of nuclear-cytoplasmic shuttling of BRCA1 and BARD1 Howdoes the nuclear shuttling ofBRCA1andBARD1regulate their function, and when does it occur? These questions are only now starting to be addressed. The only activity of either BRCA1orBARD1that is yet known to be influenced by nuclear import/export is their ability to induce apoptosis when overexpressed; apoptotic activity of both BRCA1(45) and of BARD1(51) is inhibited by at least 50% when the two proteins are co-expressed in cells."; prov:wasQuotedFrom pubmed:16108063 . sub:_4 rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:16108063; prov:wasDerivedFrom beldoc:, sub:_3 . } sub:pubinfo { this: dct:created "2014-07-03T14:30:37.691+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }