http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#Head http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#assertion http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#provenance http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#assertion http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1309469 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_1 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0045445 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"myoblast differentiation") -> r(MGI:Casq2) http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_3 http://www.w3.org/ns/prov#value We have combined genome-wide transcription factor binding and expression profiling to assemble a regulatory network controlling the myogenic differentiation program in mammalian cells. We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2 (MEF2). We discovered that MRFs and MEF2 regulate a remarkably extensive array of transcription factor genes that propagate and amplify the signals initiated by MRFs. We found that MRFs play an unexpectedly wide-ranging role in directing the assembly and usage of the neuromuscular junction. Interestingly, these factors also prepare myoblasts to respond to diverse types of stress. Computational analyses identified novel combinations of factors that, depending on the differentiation state, might collaborate with MRFs. Our studies suggest unanticipated biological insights into muscle development and highlight new directions for further studies of genes involved in muscle repair and responses to stress and damage. http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15706034 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15706034 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#_3 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://purl.org/dc/terms/created 2014-07-03T14:30:32.232+02:00 http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3MciUkM0wGtVNUDTDMgJnnBVOBGnvJAmH_vamZDqYxU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234