http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#Head http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#assertion http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#provenance http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#assertion http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_2 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_3 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=10901 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7553 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_4 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_5 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_5 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7553 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_4 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_1 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:SKP2),p(HGNC:MYC)) -> tscript(p(HGNC:MYC)) http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_7 http://www.w3.org/ns/prov#value Inhibition of either KPC1 or KPC2 by RNA interference or with dominant-negative mutants delays p27 degradation at the G0 G1 transition . These results indicate that the degradation of p27 is regulated by two distinct mechanisms: translocation-coupled cytoplasmic ubiquitylation by KPC at the G0 G1 transition and nuclear ubiquitylation by SKP2 during S and G2 phases (see Supplementary information S2 (figure)). Given that, in a subset of breast cancers (32 out of 84 samples)45, p27 levels were low despite SKP2 not being expressed, it remains possible that the expression of KPC might be elevated in such cases. Surprisingly, SKP2 also binds to MYC through its MB2 and helix loop helix leucine zipper (HLHZip) domains, and thereby mediates its ubiquitylation and degradation. However, SKP2 unexpectedly increases the transactivation activity of MYC, indicating that SKP2 is a transcriptional cofactor. Consistent with this notion, MYC accumulates, but its transcriptional activity is reduced, in mouse Skp2 ko cells. http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16633365 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16633365 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#_7 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://purl.org/dc/terms/created 2014-07-03T14:32:59.944+02:00 http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3ILQS6xzpfqjRXkI_hW2VunTItIr8OV3Mt85bvf1gjI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234