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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#_5 http://www.w3.org/ns/prov#value Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2.tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE). Interestingly, TBH also induces rat GCLC, but the rat GCLC promoter lacks ARE. This study examined the role of Nrf1 and Nrf2 in the transcriptional regulation of rat GCLC. The baseline and TBH-mediated increase in GCLC mRNA levels and rat GCLC promoter activity were lower in Nrf1 and Nrf2 null (F1 and F2) fibroblasts than in wild-type cells.Overexpression of Nrf1 and Nrf2 in respective cells restored the rat GCLC promoter activity and response to TBH but not if the AP-1 and NF-kappaB binding sites were mutated. http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15988009 http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15988009 http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#_5 http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk http://purl.org/dc/terms/created 2014-07-03T14:30:36.251+02:00 http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3DjGlSuuAUcEhZxrRJJWsLfWlMOpYjenBp0LBGN0ivk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234