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http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_2 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000842 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_4 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_1 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#assertion http://www.w3.org/2000/01/rdf-schema#label kin(complex(SCOMP:"p85/p110 PI3Kinase Complex")) -> (p(HGNC:CD28) -> p(HGNC:IL17A)) http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:CD28) -> p(HGNC:IL17A) http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_6 http://www.w3.org/ns/prov#value Incubation of PBMCs with 10 microgram/ml anti-CD3 significantly upregulated IL-17 production upto 3.7 fold, and combination of anti-CD3 and anti-CD28 produced more IL-17 (approximately 1.3-1.5 fold) than anti-CD3 alone. Furthermore, treatment with LY294002 and wortmannin, inhibitors of PI3K, and PDTC, NFkB inhibitor markedly blocked the anti-CD3 and anti-CD28 induced IL17 protein and mRNA production in a dose dependent manner. This indicates that CD3 and CD28 induced IL-17 production was mediated by PI3K pathway. http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15642134 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15642134 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#_6 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk http://purl.org/dc/terms/created 2014-07-03T14:32:37.447+02:00 http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3A_l5aeNI4q0u1GWfRYR54P3o8FTudBp4ZN6R-_Uqsk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234