. . . . . . . . . . . . . . . . . . . . . "kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\")) -> (p(HGNC:CD28) -> p(HGNC:IL17A))" . "p(HGNC:CD28) -> p(HGNC:IL17A)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Incubation of PBMCs with 10 microgram/ml anti-CD3 significantly upregulated IL-17 production upto 3.7 fold, and combination of anti-CD3 and anti-CD28 produced more IL-17 (approximately 1.3-1.5 fold) than anti-CD3 alone. Furthermore, treatment with LY294002 and wortmannin, inhibitors of PI3K, and PDTC, NFkB inhibitor markedly blocked the anti-CD3 and anti-CD28 induced IL17 protein and mRNA production in a dose dependent manner. This indicates that CD3 and CD28 induced IL-17 production was mediated by PI3K pathway." . . "Selventa" . . . . "2014-07-03T14:32:37.447+02:00"^^ . . .