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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#_6 http://www.w3.org/ns/prov#value The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the characterization of human and murine E2F8, a new member of the E2F family. Sequence analysis of E2F8 predicts the presence of two distinct E2F-related DNA binding domains suggesting that E2F8 and, the recently, identified E2F7 form a subgroup within the E2F family. We show that E2F transcription factors bind the E2F8 promoter in vivo and that expression of E2F8 is being induced at the G1/S transition. Purified recombinant E2F8 binds specifically to a consensus E2F-DNA-binding site indicating that E2F8, like E2F7, binds DNA without the requirement of co-factors such as DP1. E2F8 inhibits E2F-driven promoters suggesting that E2F8 is transcriptional repressor like E2F7. Ectopic expression of E2F8 in diploid human fibroblasts reduces expression of E2F-target genes and inhibits cell growth consistent with a role for repressing E2F transcriptional activity. Taken together, these data suggest that E2F8 has an important role in turning of the expression of E2F-target genes in the S-phase of the cell cycle. http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16179649 http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16179649 http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#_6 http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY#pubinfo http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY http://purl.org/dc/terms/created 2014-07-03T14:30:38.313+02:00 http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA37cETEYHNwNBjfGvXBSo31fHJq2Q8dFjtHXOvy89FxY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234