@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA32U4Zq-teDv4k_rrvovFwIGqi7b2T1MuoJgODNu1UrQ> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA32U4Zq-teDv4k_rrvovFwIGqi7b2T1MuoJgODNu1UrQ#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 hasAgent: sub:_2 ;
    a go:0016301 .
  sub:_2 geneProductOf: hgnc:1773 ;
    a Protein: .
  sub:_3 occursIn: species:9606 ;
    rdf:object sub:_1 ;
    rdf:predicate belv:directlyDecreases ;
    rdf:subject schem:Flavopiridol ;
    a rdf:Statement .
  sub:assertion rdfs:label "a(SCHEM:Flavopiridol) =| kin(p(HGNC:CDK4))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Flavopiridol (L-868275) is one of only two CDKIs to reach human clinical trials. It is a synthetic flavone, derived from the flavonoid rohitukine. It achieves antitumor activity through a variety of mechanisms, including inhibition of cell growth and proliferation, induction of apoptosis, and inhibition of angiogenesis. This agent is a broad spectrum phosphokinase inhibitor with the strongest activity against CDKs (specifically CDK1, CDK2, CDK4, CDK6, and CDK7), although interactions with the EGFR family of receptors, receptor associated protein kinases, and protein kinase C have also been reported" ;
    prov:wasQuotedFrom pubmed:15320717 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15320717 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:30:27.078+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}