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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#_5 http://www.w3.org/ns/prov#value Site-directed mutagenesis identified phenylalanine 79 and tyrosine 80 within the 3(10) helix region of p57 as crucial residues for kinase inhibition, supporting the structural evidence that the 3(10) helix binds deep inside the catalytic cleft of Cdk2, mimicking ATP. Mutations within the 3(10) helix region of the p57 molecule completely abolished the ability to arrest the cell cycle at G1 in vivo. These results indicate that this region is specifically utilized by p57 in selectively inhibiting cyclin A or E/Cdk2+ activities. Thus the 3(10) helix motif may confer a specific regulatory mechanism by which p57 differentially regulates Cdk2 and Cdk4 activities. http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9632724 http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9632724 http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#_5 http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus#pubinfo http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus http://purl.org/dc/terms/created 2014-07-03T14:34:09.617+02:00 http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA32HpsywKOhNcgd_SCa4x1yIETGOb20AUmcoK9FRLJus http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234