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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#_6 http://www.w3.org/ns/prov#value ere, we show that all three of the ubiquitously expressed JAKs--JAK1, JAK2, and Tyk2--become phosphorylated on tyrosine in both mouse BALB/c 3T3 cells and human fibroblasts engineered to express the PDGF-beta receptor. All three proteins are also associated with the activated receptor. Through the use of cell lines each lacking an individual JAK, we find that in contrast to interferon signaling, PDGF-induced JAK phosphorylation and activation of STAT1 and STAT3 is independent of the presence of any other single JAK but does require receptor tyrosine kinase activity. http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8657151 http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8657151 http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#_6 http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s#pubinfo http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s http://purl.org/dc/terms/created 2014-07-03T14:33:52.155+02:00 http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA3-fSMqDcKJldwLPcWBvnMCBaY8dplF7Yk1pHO6UV_1s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234