http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#Head http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#assertion http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#provenance http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#pubinfo http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#assertion http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_2 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1913695 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D006321 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_1 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0006979 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"response to oxidative stress") -| cat(p(MGI:Cyc1)) http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_4 http://www.w3.org/ns/prov#value we determined whether the oxidative stress that occurs in response to T. cruzi infection contributes to the catalytic impairment of respiratory complexes and to subsequent mitochondrial dysfunction in murine myocardium. Our data show that oxidative injuries, as determined by the levels of lipid peroxides and protein carbonyls, are incurred in cardiac mitochondria as early as 3 days postinfection and persist throughout the infection and disease. We observed substantial carbonylation of the specific subunits of mitochondrial respiratory complexes in infected murine hearts. Of note is the oxidative modification of NDUFS1, NDUFS2, and NDUFV1, which form the catalytic core of the CI complex; UQCRC1, UQCRC2, and UQCRQ, the subunits of the core subcomplex, and UQCRH and CYC1, which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent of oxidative modifications of the subunits correlated with the catalytic defects of the respiratory complexes in the infected myocardium. Taken together, our data demonstrate that respiratory complexes are oxidatively damaged in response to the stress of T. cruzi infection. These data also suggest involvement of the specific susceptibility of the protein subunits, and not generalized mitochondrial oxidative damage in respiratory chain impairment of chagasic hearts. http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15544925 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15544925 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#_4 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4#pubinfo http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://purl.org/dc/terms/created 2014-07-03T14:30:29.565+02:00 http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA2nwSv7qjCOfFFqmxkQqJkvsBLK-W5qiiHTk0g6XU3V4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234