@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA2kwXio_a7pMnd3rNG8ApmmrWKaxczCchia_rliCnmlY> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA2kwXio_a7pMnd3rNG8ApmmrWKaxczCchia_rliCnmlY#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:5344;
    a Protein: .
  
  sub:_2 geneProductOf: hgnc:11765;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:7515;
    a Protein: .
  
  sub:_4 rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_2;
    a rdf:Statement .
  
  sub:_5 occursIn: obo:CLO_0008080, obo:CL_0000066, obo:UBERON_0001005, species:9606;
    rdf:object sub:_4;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:ICAM1) -> (p(HGNC:TGFA) -> p(HGNC:MUC5AC))", "p(HGNC:TGFA) -> p(HGNC:MUC5AC)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value "MUC5AC mucin was measured in cell lysates (filled columns) and in cell supernatants (open columns) by ELISA in confluent cultures of human airway (NCI-H292) epithelial cells incubated for 24 h with medium alone (?TGF-alpha; control), medium alone + 5 ?g/ml of ICAM-1 neutralizing antibody (Ab) (which prevents ligand binding to the first extracellular domain of ICAM-1), or with added TGF-alpha (5 ng/ml; +TGF-alpha) + increasing concentrations of an ICAM-1 neutralizing antibody or + an isotype-matched control antibody (IgG1; 5 ?g/ml). The EGFR ligand TGF-alpha (5 ng/ml, 24 h) increased mucin production 3.5-fold in human airway (NCI-H292) epithelial cells (Fig. 1A). An ICAM-1 neutralizing antibody that prevents ICAM-1 ligand binding to the first extracellular domain of ICAM-1 decreased TGF-alpha-induced mucin production dose-dependently by 60% (Fig. 1A).";
    prov:wasQuotedFrom pubmed:19429776 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:19429776;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:34.725+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}