sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_6 prov:value "MUC5AC mucin was measured in cell lysates (filled columns) and in cell supernatants (open columns) by ELISA in confluent cultures of human airway (NCI-H292) epithelial cells incubated for 24 h with medium alone (?TGF-alpha; control), medium alone + 5 ?g/ml of ICAM-1 neutralizing antibody (Ab) (which prevents ligand binding to the first extracellular domain of ICAM-1), or with added TGF-alpha (5 ng/ml; +TGF-alpha) + increasing concentrations of an ICAM-1 neutralizing antibody or + an isotype-matched control antibody (IgG1; 5 ?g/ml). The EGFR ligand TGF-alpha (5 ng/ml, 24 h) increased mucin production 3.5-fold in human airway (NCI-H292) epithelial cells (Fig. 1A). An ICAM-1 neutralizing antibody that prevents ICAM-1 ligand binding to the first extracellular domain of ICAM-1 decreased TGF-alpha-induced mucin production dose-dependently by 60% (Fig. 1A)." ;
    prov:wasQuotedFrom pubmed:19429776 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:19429776 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}