sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_5 ; pav:version "20131211" . sub:_4prov:value "Shn-2-deficient developing Th2 cells showed constitutive activation of nuclear factor kappaB (NF-kappaB) and enhanced GATA3 induction. . . Increased amounts of p65 supershift band were detected after anti-TCR stimulation in Shn-2–/– T cells. Furthermore, an EMSA with anti-p50 antibody revealed that most of the NF-{kappa}B EMSA band detected in nonstimulated Shn-2–/– T cells contained the p50 subunit (Fig. 4 B, lane 11). There was a substantial increase in the level of the p50 band after anti-TCR stimulation (Fig. 4 B, lane 12). These results suggest that NF-{kappa}B is constitutively activated in Shn-2–/– CD4 T cells and it is hyperactivated after anti-TCR stimulation." ; prov:wasQuotedFrompubmed:15699073 . sub:_5rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:15699073 ; prov:wasDerivedFrombeldoc: , sub:_4 . }