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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#_5 http://www.w3.org/ns/prov#value we transiently transfected the wild-type and CD40 cytoplasmic domain mutants with a plasmid containing the NF-kappaB response element upstream of a luciferase gene (pNF-kappaB-luc) and 2 ug of a Renilla luciferase (pHRL-luc) plasmid to normalize for transfection efficiency. The cells were subsequently stimulated via CD40 using CHO-CD154 for 16 h. Stimulation of both the wild-type and hCD 32 mutant resulted in a 3-fold induction of NF-kappaB luciferase activity above background, whereas stimulation of the hCD40EEAA mutant did not result in detectable stimulation of NF-kappaB reporter activity (Fig. 9A). Thus, optimal NF-kappaB activation requires an intact TRAF6 binding domain of CD40. http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15634933 http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15634933 http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#_5 http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E#pubinfo http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E http://purl.org/dc/terms/created 2014-07-03T14:30:30.680+02:00 http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA2cZbZxXoJVEsnG8LdPIFUYcwLC97A0mDys4NZGU308E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234