. . . . . . . . . . . . . . . . "cat(p(HGNC:CD40)) -> tscript(complex(NCH:\"Nfkb Complex\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "we transiently transfected the wild-type and CD40 cytoplasmic domain mutants with a plasmid containing the NF-kappaB response element upstream of a luciferase gene (pNF-kappaB-luc) and 2 ug of a Renilla luciferase (pHRL-luc) plasmid to normalize for transfection efficiency. The cells were subsequently stimulated via CD40 using CHO-CD154 for 16 h. Stimulation of both the wild-type and hCD 32 mutant resulted in a 3-fold induction of NF-kappaB luciferase activity above background, whereas stimulation of the hCD40EEAA mutant did not result in detectable stimulation of NF-kappaB reporter activity (Fig. 9A). Thus, optimal NF-kappaB activation requires an intact TRAF6 binding domain of CD40." . . "Selventa" . . . . "2014-07-03T14:30:30.680+02:00"^^ . . .