@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA2Ip1HSp8kTM-OOQ2uYxoRoUnm8dWNpF2StUS3p-TVKY> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA2Ip1HSp8kTM-OOQ2uYxoRoUnm8dWNpF2StUS3p-TVKY#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: sub:_2, sub:_3;
    a ProteinComplex: .
  
  sub:_2 geneProductOf: hgnc:738;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:6993;
    a Protein: .
  
  sub:_4 hasAgent: sub:_5;
    a go:0042789 .
  
  sub:_5 geneProductOf: hgnc:6993;
    a Protein: .
  
  sub:_6 occursIn: obo:CL_0002518, species:9606;
    rdf:object sub:_4;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "complex(p(HGNC:ASCL1),p(HGNC:MEF2A)) => tscript(p(HGNC:MEF2A))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_8;
    pav:version "20131211" .
  
  sub:_7 prov:value "Cotransfection of CV1 cells with the TKCAT reporter construct and the expression constructs for either MEF2A or MASH1 produced no significant change in reporter gene activity (Fig. 2B). However, coexpression of both MEF2A and MASH1 together resulted in a significant increase in CAT reporter activity. That this induction was due to interaction of the respective transcription factors with their DNA binding sites was supported by the demonstration that point mutations in either the E box or the MEF2 binding site, which in DNA mobility shift assays disrupted MASH1 or MEF2A binding, respectively (data not shown), rendered the reporter gene unresponsive to both MASH1 and MEF2A individually or in combination (Fig. 2B).";
    prov:wasQuotedFrom pubmed:8662987 .
  
  sub:_8 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:8662987;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:52.166+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}