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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#_6 http://www.w3.org/ns/prov#value Mutation of Lys650-->Glu in the activation loop of the FGFR3 kinase domain causes the lethal human skeletal disorder thanatophoric dysplasia type II (TDII) and is also found in patients with multiple myeloma, bladder and cervical carcinomas. This mutation leads to constitutive activation of FGFR3. We show that the kinase domains of FGFR1, FGFR3, and FGFR4 containing the activation loop mutation, when targeted to the plasma membrane by a myristylation signal, can transform NIH3T3 cells and induce neurite outgrowth in PC12 cells. Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated by all three 'TDII-like' FGFR derivatives. Additionally, activation of Stat1 and Stat3 was observed in cells expressing the activated FGFR derivatives. Finally, we demonstrate that FGFR1, FGFR3, and FGFR4 derivatives can stimulate PI-3 kinase activity. http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10918587 http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10918587 http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#_6 http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw#pubinfo http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw http://purl.org/dc/terms/created 2014-07-03T14:31:36.409+02:00 http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA2I597CfSAIWXAUbfKL_LgWScLFBn16u2L46Psfzldmw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234