[ {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00864",
    "@type" : [ "http://bio2rdf.org/drugbank_vocabulary:Drug" ],
    "http://bio2rdf.org/bio2rdf_vocabulary:identifier" : [ {
      "@value" : "DB00864"
    } ],
    "http://bio2rdf.org/bio2rdf_vocabulary:namespace" : [ {
      "@value" : "drugbank"
    } ],
    "http://bio2rdf.org/bio2rdf_vocabulary:uri" : [ {
      "@value" : "http://bio2rdf.org/drugbank:DB00864"
    } ],
    "http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org" : [ {
      "@id" : "http://identifiers.org/drugbank/DB00864"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:drugbank-id" : [ {
      "@value" : "APRD00276"
    }, {
      "@value" : "DB00864"
    }, {
      "@value" : "EXPT01437"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-ahfs" : [ {
      "@id" : "http://bio2rdf.org/ahfs:84:92.00"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-atc" : [ {
      "@id" : "http://bio2rdf.org/atc:D11AH01"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-cas" : [ {
      "@id" : "http://bio2rdf.org/cas:104987-11-3"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-chebi" : [ {
      "@id" : "http://bio2rdf.org/chebi:61049"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-dpd" : [ {
      "@id" : "http://bio2rdf.org/dpd:2243144"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-kegg" : [ {
      "@id" : "http://bio2rdf.org/kegg:C01375"
    }, {
      "@id" : "http://bio2rdf.org/kegg:D00107"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-ndc" : [ {
      "@id" : "http://bio2rdf.org/ndc:0469-0607-73"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pdb" : [ {
      "@id" : "http://bio2rdf.org/pdb:FK5"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb" : [ {
      "@id" : "http://bio2rdf.org/pharmgkb:PA451578"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound" : [ {
      "@id" : "http://bio2rdf.org/pubchem.compound:445647"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance" : [ {
      "@id" : "http://bio2rdf.org/pubchem.substance:46506004"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-wikipedia" : [ {
      "@id" : "http://bio2rdf.org/wikipedia:Tacrolimus"
    } ],
    "http://purl.org/dc/terms/description" : [ {
      "@language" : "en",
      "@value" : "Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription."
    } ],
    "http://purl.org/dc/terms/identifier" : [ {
      "@value" : "drugbank:DB00864"
    } ],
    "http://purl.org/dc/terms/title" : [ {
      "@language" : "en",
      "@value" : "Tacrolimus"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@language" : "en",
      "@value" : "Tacrolimus [drugbank:DB00864]"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#seeAlso" : [ {
      "@id" : "http://www.drugbank.ca/drugs/DB00864"
    }, {
      "@id" : "http://www.drugs.com/cdi/tacrolimus.html"
    }, {
      "@id" : "http://www.rxlist.com/cgi/generic2/tacrolimus.htm"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#publicationInfo"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#head"
}, {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#assertion",
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz"
    } ]
  }, {
    "@id" : "http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3",
    "http://www.w3.org/ns/dcat#distribution" : [ {
      "@id" : "http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz"
    } ]
  }, {
    "@id" : "http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2015-01-09T17:00:50-05:00"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00"
    } ]
  }, {
    "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip",
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "http://drugbank.ca"
    } ]
  }, {
    "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00",
    "http://purl.org/pav/retrievedOn" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-11-12T07:57:03-05:00"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2018-03-30T11:11:14.340+02:00"
    } ],
    "http://purl.org/dc/terms/license" : [ {
      "@id" : "https://creativecommons.org/licenses/by-nc/4.0/"
    } ],
    "http://purl.org/nanopub/x/hasSignatureElement" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#signature.MC0CFHL4yZObHR-d"
    } ],
    "http://www.w3.org/ns/prov#wasGeneratedBy" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475"
    } ]
  }, {
    "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#signature.MC0CFHL4yZObHR-d",
    "http://purl.org/nanopub/x/hasPublicKey" : [ {
      "@value" : "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"
    } ],
    "http://purl.org/nanopub/x/hasSignature" : [ {
      "@value" : "MC0CFHL4yZObHR+d1m5pBpIO2iwJ8nJvAhUAhdUClhls6ZuKAvjHB/11/60sSIk="
    } ],
    "http://purl.org/nanopub/x/signedBy" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB"
    } ]
  }, {
    "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB",
    "http://www.w3.org/ns/prov#specializationOf" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub"
    } ],
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  }, {
    "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475",
    "http://purl.org/dc/terms/identifier" : [ {
      "@value" : "7720f136-841b-4851-a6e4-ad20a409a475"
    } ],
    "http://www.w3.org/ns/prov#used" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349"
    } ],
    "http://www.w3.org/ns/prov#wasAssociatedWith" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB"
    } ],
    "http://www.w3.org/ns/prov#wasStartedBy" : [ {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  }, {
    "@id" : "https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349",
    "http://purl.org/dc/terms/isVersionOf" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "eda7951a5f6c622c5d2132f50c3093138484a349"
    } ],
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#publicationInfo"
} ]