http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#head http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#assertion http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#provenance http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#publicationInfo http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#assertion http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB00715 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB00715 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB00715 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-ahfs http://bio2rdf.org/ahfs:28:16.04.20 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-atc http://bio2rdf.org/atc:N06AB05 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-bindingdb http://bio2rdf.org/bindingdb:22416 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:61869-08-7 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-chebi http://bio2rdf.org/chebi:7936 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:39888 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-dpd http://bio2rdf.org/dpd:2262746 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:C07415 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:D02362 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-ndc http://bio2rdf.org/ndc:0029-3210-13 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA450801 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:43815 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46504821 http://bio2rdf.org/drugbank:DB00715 http://bio2rdf.org/drugbank_vocabulary:x-wikipedia http://bio2rdf.org/wikipedia:Paroxetine http://bio2rdf.org/drugbank:DB00715 http://purl.org/dc/terms/description Paroxetine hydrochloride and paroxetine mesylate belong to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D₂ or histamine H₁ receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT_1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT_1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a complete listing of side effects). Side effects generally occur during the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Paroxetine hydrochloride and mesylate are considered therapeutic alternatives rather than generic equivalents by the US Food and Drug Administration (FDA); both agents contain the same active moiety (i.e. paroxetine), but are formulated as different salt forms. Clinical studies establishing the efficacy of paroxetine in various conditions were performed using paroxetine hydrochloride. Since both agents contain the same active moiety, the clinical efficacy of both agents is thought to be similar. Paroxetine may be used to treat major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). Paroxetine has the most evidence supporting its use for anxiety-related disorders of the SSRIs. It has the greatest anticholinergic activity of the agents in this class and compared to other SSRIs, paroxetine may cause greater weight gain, sexual dysfunction, sedation and constipation. http://bio2rdf.org/drugbank:DB00715 http://purl.org/dc/terms/identifier drugbank:DB00715 http://bio2rdf.org/drugbank:DB00715 http://purl.org/dc/terms/title Paroxetine http://bio2rdf.org/drugbank:DB00715 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB00715 http://www.w3.org/2000/01/rdf-schema#label Paroxetine [drugbank:DB00715] http://bio2rdf.org/drugbank:DB00715 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB00715 http://bio2rdf.org/drugbank:DB00715 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugs.com/paroxetine.html http://bio2rdf.org/drugbank:DB00715 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.rxlist.com/cgi/generic/parox.htm http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#provenance http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#publicationInfo http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#signature.MC0CFQCGYDWNgMsg http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#signature.MC0CFQCGYDWNgMsg http://purl.org/nanopub/x/hasSignature MC0CFQCGYDWNgMsg/6UQHqnqHgyH9IHPxQIUUpjCL2HsXNdaXF6K2uJL49qLLpw= http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#signature.MC0CFQCGYDWNgMsg http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://purl.org/dc/terms/created 2018-03-30T11:11:08.976+02:00 http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0#signature.MC0CFQCGYDWNgMsg http://bio2rdf.org/drugbank:DB00715_nanopub.RA2BVAf36WbD2WCdngrERI4FXelin_PHVNh81LjTvy3A0 http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234