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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA1UnUbhsvdou13s6lfDozr9B-AkrHEdqBN4Obn7MyUzo#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA1UnUbhsvdou13s6lfDozr9B-AkrHEdqBN4Obn7MyUzo#_5 http://www.w3.org/ns/prov#value Transfection of U87MG and T691 cells with Gab1 and SHP-2 independently with NF-kB-luciferase reporter construct which showed a 9-fold increase in luciferase activity in both U87MG transfected cells and U87MG/T691 compared with the empty vector and cotransfection of Gab1 with SHP-2 resulted in additional upregulation of NF-kB activity. Furthermore, cotransfection with a construct expressing myristoylated Akt increased NF-kB activity in parental and T691 cells by 4 and 3-fold respectively over the empty vector but no change when expressed with mutant Akt. 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