http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#Head http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#assertion http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#provenance http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#assertion http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1340094 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D009504 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0016477 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_1 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Cxcl2) -> bp(GO:"cell migration") http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_3 http://www.w3.org/ns/prov#value Fig. 6 Model of TLR4 and chemokine receptor crosstalk. MIP-2 binding to CXCR2 induces PMN migration, as well as GRK2 and GRK5 expression, through PI3K-? signaling. Increased GRK2 and GRK5 expression results in chemokine receptor internalization and desensitization, thereby negatively regulating PMN migration. Thus, PI3K-?-activated signaling is postulated to be a feedback mechanism regulating PMN migration. Because persistent infection requires continued PMN infiltration, LPS acting through the TLR4 signaling pathway transcriptionally downregulates expression of GRK2 and GRK5 in response to MIP-2. This decreases chemokine receptor desensitization by preventing CXCR2 internalization and thus augments PMN migration. MEK kinase is involved in mediating the crosstalk between TLR4 and chemokine receptors. Dashed lines indicate inhibitory signals. http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12592402 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12592402 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#_3 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://purl.org/dc/terms/created 2014-07-03T14:30:10.213+02:00 http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA1Lm_yekF2LBcIqDR51M0BWnG7CbRdd1J0YbojmQwePw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234