http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#Head http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#assertion http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#provenance http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#assertion http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_2 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:94912 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0006300 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_1 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#assertion http://www.w3.org/2000/01/rdf-schema#label cat(p(MGI:Dnmt1)) -> bp(GOBP:"mismatch repair") http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_4 http://www.w3.org/ns/prov#value We have developed a model system to analyze the effects of DNA methyltransferase 1 (Dnmt1) deficiency on DNA mismatch repair (MMR) in mouse embryonic stem (ES) cells. We found that Dnmt1 deficiency led to a 7-fold increase in the microsatellite slippage rate. Interestingly, the region flanking the mononucleotide repeat was unmethylated regardless of Dnmt1 status, suggesting that it is not the local levels of DNA methylation that direct the increase in microsatellite instability (MSI). The enhanced MSI was associated with higher levels of histone H3 acetylation and lower MeCP2 binding at regions near the assayed microsatellite, suggesting that Dnmt1 loss may decrease MMR efficiency by modifying chromatin structure. http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15509869 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15509869 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#_4 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://purl.org/dc/terms/created 2014-07-03T14:32:33.853+02:00 http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA1EuU_LBFztOyBxfTxaMeS70dwxyxpuUfdbDoRZldq4U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234