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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#_4 http://www.w3.org/ns/prov#value At 4 weeks of age, in the fed state, Ncb5or -/- mice had normal blood glucose levels (Fig. 2a) but insulin levels were 40% those of wild-type littermates (Fig. 2b). These animals had impaired tolerance to an i.p. injection of glucose (Fig. 2c), suggesting decreased insulin reserve, i.e., prediabetes. By 7 weeks of age, the blood glucose levels in Ncb5or -/- mice were 3-fold higher than those in +/+ mice during the fed state or after an overnight fast (Fig. 2a). The hyperglycemia in the Ncb5or -/- animals was associated with a marked reduction in plasma insulin. In the fed state, insulin levels of 7-week-old Ncb5or -/- animals were decreased to 25% of the levels in normal animals (Fig. 2b). Insulin was barely detectable in the plasma of fasting Ncb5or -/- animals (data not shown). These data indicate that, between 4 and 7 weeks of age, there was a progressive deterioration of glucose homeostasis in Ncb5or -/- mice. http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15247412 http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15247412 http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#_4 http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo#pubinfo http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo http://purl.org/dc/terms/created 2014-07-03T14:30:25.814+02:00 http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA1E9358yEMGxyGBkNOq5BlfhbUZEYdsj87lJXPlLNbWo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234