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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#_3 http://www.w3.org/ns/prov#value From our cDNA microarray experiments, we determined that a variety of nucleotide synthesis-related genes, including TS, were downregulated with lapatinib, and this was apparent in HER2-amplified cells (SNU216 gastric cancer cell line). Figure 2. Lapatinib downregulates fluoropyrimidine-target genes. The expressions of representative nucleotide synthesis-related genes [E2F-1, TS, TK1 (thymidine kinase 1), DHFR(dihydrofolate reductase), RRM2 (ribonucleotide reductase M2 polypeptide), DUT (DUTP pyrophosphatase), NME1 (nuclear diphosphate kinase 1)] were reduced as the result of gefitinib or lapatinib treatment in TKI-sensitive cells. http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19529774 http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19529774 http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#_3 http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc http://purl.org/dc/terms/created 2014-07-03T14:33:34.851+02:00 http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA0ztOs6XYSNVH8DYEMHgL9z7k2_2s2vKEwsCCzxRzEwc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234