http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#Head http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#assertion http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#provenance http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#assertion http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_1 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=2019 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0002368 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_1 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0001666 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GOBP:"response to hypoxia") -| p(RGD:Aco1) http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_3 http://www.w3.org/ns/prov#value With the use of fibroblasts, hepatoma cells, and macrophages in culture, NO has been shown to increase IRP RNA-binding activity, resulting in increased TfR-1 expression and reduced ferritin translation.1-5 The mechanism behind this increase in IRP RNA- binding activity may be a result of the NO-mediated depletion of cellular iron or the ability of NO to directly disassemble the [4Fe-4S] cluster of IRP-1 to increase RNA-binding activity.1,2 However, these studies con- flict with other investigations involving macrophages showing that inflammation or incubation with interferon /lipopolysaccharide leads to marked NO production that stimulates ferritin synthesis and decreases TfR-1 mRNA levels.6-10 This effect was caused by NO as inhibitors of nitric oxide synthase prevented the response. 10 Moreover, the increase in ferritin and decrease in TfR-1 expression were mediated by IRP-2, evidenced by a marked decrease in its RNA-binding activity.8-10 The findings of recent studies9,10 have suggested that the different effects of NO described above are a result of the various redox-related states of this molecule generated under different conditions, eg, the nitrosonium ion [NO+] and nitric oxide [NO-]. For instance, the effect of NO in mediating increased IRP RNA binding activity may be mediated by NO-; as it avidly binds iron and could result in iron release from IRP-1 and the cell.10 Exposure of macrophages to inflammatory cytokines may generate NO, which then S-nitrosylates IRP-2 and results in its degradation, leading to increased ferritin translation.10 However, further studies are required to confirm this hypothesis, as there is no direct evidence that IRP-2 is S-nitrosylated by NO The effects of hypoxia on iron metabolism can also be at least partly linked to the changes in RNA-binding activity of the IRPs. Indeed, IRP-1 RNA-binding activity has been shown to decrease in macrophages and hepatoma cells during hypoxia,11,12 and these conditions are known to increase ferritin expression.13 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12761471 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12761471 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#_3 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://purl.org/dc/terms/created 2014-07-03T14:32:02.316+02:00 http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234