@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA0vXTsdUHDr0pea4XSfyYr8dfo-YMnHV-xZpzaNsBleA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: rgd:2019;
    a Protein: .
  
  sub:_2 occursIn: obo:CL_0002368, species:10116;
    rdf:object sub:_1;
    rdf:predicate belv:decreases;
    rdf:subject go:0001666;
    a rdf:Statement .
  
  sub:assertion rdfs:label "bp(GOBP:\"response to hypoxia\") -| p(RGD:Aco1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "With the use of fibroblasts, hepatoma cells, and macrophages in culture, NO has been shown to increase IRP RNA-binding activity, resulting in increased TfR-1 expression and reduced ferritin translation.1-5 The mechanism behind this increase in IRP RNA- binding activity may be a result of the NO-mediated depletion of cellular iron or the ability of NO to directly disassemble the [4Fe-4S] cluster of IRP-1 to increase RNA-binding activity.1,2 However, these studies con- flict with other investigations involving macrophages showing that inflammation or incubation with interferon /lipopolysaccharide leads to marked NO production that stimulates ferritin synthesis and decreases TfR-1 mRNA levels.6-10 This effect was caused by NO as inhibitors of nitric oxide synthase prevented the response. 10 Moreover, the increase in ferritin and decrease in TfR-1 expression were mediated by IRP-2, evidenced by a marked decrease in its RNA-binding activity.8-10 The findings of recent studies9,10 have suggested that the different effects of NO described above are a result of the various redox-related states of this molecule generated under different conditions, eg, the nitrosonium ion [NO+] and nitric oxide [NO-]. For instance, the effect of NO in mediating increased IRP RNA binding activity may be mediated by NO-; as it avidly binds iron and could result in iron release from IRP-1 and the cell.10 Exposure of macrophages to inflammatory cytokines may generate NO, which then S-nitrosylates IRP-2 and results in its degradation, leading to increased ferritin translation.10 However, further studies are required to confirm this hypothesis, as there is no direct evidence that IRP-2 is S-nitrosylated by NO The effects of hypoxia on iron metabolism can also be at least partly linked to the changes in RNA-binding activity of the IRPs. Indeed, IRP-1 RNA-binding activity has been shown to decrease in macrophages and hepatoma cells during hypoxia,11,12 and these conditions are known to increase ferritin expression.13";
    prov:wasQuotedFrom pubmed:12761471 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12761471;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:02.316+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}