@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v3.0.0/void/> .

dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_head {
  this: np:hasAssertion dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_assertion;
    np:hasProvenance dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_provenance;
    np:hasPublicationInfo dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_assertion a np:Assertion .
  
  dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_provenance a np:Provenance .
  
  dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_assertion {
  miriam-gene:847 a ncit:C16612 .
  
  lld:C0149925 a ncit:C7057 .
  
  dgn-gda:DGN3dcc013968a39e8130306fb8defa80e0 sio:SIO_000628 miriam-gene:847, lld:C0149925;
    a sio:SIO_001121 .
}

dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_provenance {
  dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_assertion dcterms:description
      "[The expression of intrinsic resistance to cisplatin in two lung cancer cell lines, one derived from a small cell carcinoma (SW1271) and the other from an adenocarcinoma (A549), relative to a drug-sensitive small cell line SW900, was characterized by: (i) expression of cross-resistance to mitomycin C and cadmium chloride, but increased sensitivity to adriamycin and etoposide; (ii) significantly decreased cisplatin uptake; (iii) elevated levels of glutathione which could be reduced by buthionine L-sulfoximine resulting in significant sensitization of the cells to cisplatin; (iv) a lack of consistent modification of metallothionein content and expression of levels of glutathione S-transferase, glutathione reductase and glutathione peroxidase or of activities of DT-diaphorase or catalase; (v) significantly reduced total DNA-platination levels immediately following a 1 h cisplatin treatment with 10 micrograms/ml (33.3 microM); (vi) increased removal of Pt-GG and Pt-AG adducts by the A549 cells, consistent with increased repair capacity, but a lack of removal of these major adducts by the SW1271 cells indicative of tolerance of this drug-induced DNA damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:8400352;
    prov:wasDerivedFrom dgn-void:befree-20150227;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP283495.RA0Vw4HDH3TgNyMvv5pGYX41ClfD3Jibju9CISIdIi1i8130_publicationInfo {
  this: dcterms:created "2015-08-25T14:40:21+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v3.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v3.0.0" .
}