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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#_3 http://www.w3.org/ns/prov#value We have examined how transient cerebral ischemia affects the mRNA expression of a family of methyl CpG-binding domain (MBD)-containing factors in the rat hippocampus. Our results show that each member of this family is affected by cerebral ischemia challenge, but with differing patterns of responsiveness. At 3, 6 and 12 h following reperfusion, MeCP2 and MBD1 expression is maintained at control levels throughout the hippocampus. At 24 h, MeCP2 and MBD1 are induced in both the CA1 and CA3 subfields. This delayed pattern of induction is in contrast to the responses of MBD2 and MBD3. Both MBD2 and MBD3 display significant changes in expression at early times following reperfusion, although their changes are opposite in direction. MBD2 expression is induced throughout the hippocampal formation at 6 h, and remains elevated at 12 and 24 h. MBD3 expression decreases as early as 3 h following insult in the CA3 and dentate gyrus, and the decreased expression remains in the vulnerable CA1 subfield at 6, 12, and 24 h. http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12421618 http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12421618 http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#_3 http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ http://purl.org/dc/terms/created 2014-07-03T14:31:56.314+02:00 http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA0V-OW1WydK0eRHNXKVjjE1k7-x4Ic2CKkDZ4xZ6gfDQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234