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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#_3 http://www.w3.org/ns/prov#value In human adipocytes, pretreatment with GC induced a dose-dependent [1.0 (control); 1.2 +/- 0.1 (50 nm); 2.2 +/- 0.2 (250 nm), P < 0.01 vs. control; 3.4 +/- 0.2 (1000 nm), P < 0.001 vs. control] and time-dependent [1.0 (1 h); 3.2 +/- 2.0 (6 h); 9.1 +/- 5.9 (24 h), P < 0.05 vs. 1 h; 4.5 +/- 2.2 (48 h)] increase in insulin-stimulated protein kinase B/akt phosphorylation. In addition, whereas insulin receptor substrate (IRS)-1 protein expression did not change, IRS-1 tyrosine phosphorylation increased.Furthermore, GC induced IRS-2 mRNA expression (2.8-fold; P < 0.05) and increased insulin-stimulated glucose uptake [1.0 (control) 1.8 +/- 0.1 (insulin) vs. 2.8 +/- 0.2 (insulin + GC); P < 0.05]. http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17711920 http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17711920 http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#_3 http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw http://purl.org/dc/terms/created 2014-07-03T14:33:12.287+02:00 http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA0M4tKDp4ivl5rxuyQVg3ru_Upop4X7ZvgEpbcjI5Duw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234